In Vivo Study on Magnetomotive Ultrasound Imaging in the Framework of Nanoparticle based Magnetic Drug Targeting
Michael Fink, Stefan J. Rupitsch, H. Ermert, Stefan Lyer
Abstract
Abstract Various medical procedures make use of magnetic nanoparticles, such as Magnetic Drug Targeting (MDT), which boosts the demand for imaging modalities that are capable of in vivo visualizing this kind of particles. Magnetomotive Ultrasound is an imaging technique that can detect tissue, which is perfused by magnetic nanoparticles. In this contribution, we investigate the suitability of Magnetomotive Ultrasound to serve as a monitoring system during MDT. With the conducted measurements, it was possible for the first time to observe in vivo the accumulation of iron-oxide nanoparticles during a Magnetic Drug Targeting cancer treatment applied to a small animal (rabbit).
Topics & Concepts
In vivoMagnetic nanoparticlesUltrasoundMagnetic resonance imagingBiomedical engineeringDrug deliveryTargeted drug deliveryNanoparticlePreclinical imagingMaterials scienceNanotechnologyMedicineRadiologyBiologyBiotechnologyCharacterization and Applications of Magnetic NanoparticlesUltrasound and Hyperthermia ApplicationsUltrasound Imaging and Elastography