Development of β-carboline-benzothiazole hybrids via carboxamide formation as cytotoxic agents: DNA intercalative topoisomerase IIα inhibition and apoptosis induction
Ramya Tokala, Surbhi Mahajan, Gaddam Kiranmai, Dilep Kumar Sigalapalli, Sravani Sana, Stephy Elza John, Narayana Nagesh, Nagula Shankaraiah
Topics & Concepts
ChemistryTopoisomeraseDNA fragmentationApoptosisCell cultureDNA ladderingBiochemistryStereochemistryIn vitroMolecular biologyProgrammed cell deathBiologyGeneticsCancer therapeutics and mechanismsSynthesis and bioactivity of alkaloidsSynthesis and Biological Evaluation