Evaluation of Parent- and Metabolite-Induced Mitochondrial Toxicities Using CYP-Introduced HepG2 cells
Akinori Takemura, Simin Gong, Tomoyuki Sato, Moemi Kawaguchi, Shuichi Sekine, Yasuhiro Kazuki, T Horie, Kousei Ito
Topics & Concepts
MetaboliteMitochondrial toxicityToxicityRotenoneMitochondrionPharmacologyCytochrome P450Programmed cell deathBiologyFlutamideBiochemistryChemistryApoptosisMetabolismGeneticsCancerOrganic chemistryAndrogen receptorProstate cancerDrug-Induced Hepatotoxicity and ProtectionLiver physiology and pathologyPharmacogenetics and Drug Metabolism