Design, synthesis, and biological evaluation of 1,2,4-triazole derivatives as potent antitubercular agents
Yu Wen, Shichun Lun, Yuxue Jiao, Wei Zhang, Tianyu Hu, Ting Liu, Fan Yang, Jie Tang, Bing Zhang, William R. Bishai, Li-Fang Yu
Topics & Concepts
Microscale thermophoresisChemistryADMECytotoxicityMycolic acidTriazoleIn silicoIC50Multiple drug resistanceStereochemistryMinimum inhibitory concentrationVero cellBiochemistryIn vitroMycobacteriumBacteriaAntibioticsBiologyOrganic chemistryGeneticsGeneClick Chemistry and ApplicationsTuberculosis Research and EpidemiologyHIV/AIDS drug development and treatment