Murine Irgm Paralogs Regulate Nonredundant Functions To Execute Host Defense to Toxoplasma gondii
Jacob Dockterman, Brian E. Fee, Gregory A. Taylor, Jörn Coers
Abstract
Gamma interferon (IFN-γ)-induced immunity-related GTPases (IRGs) confer cell-autonomous immunity to the intracellular protozoan pathogen Toxoplasma gondii . Effector IRGs are loaded onto the Toxoplasma -containing parasitophorous vacuole (PV), where they recruit ubiquitin ligases, ubiquitin-binding proteins, and IFN-γ-inducible guanylate-binding proteins (Gbps), prompting PV lysis and parasite destruction.
Topics & Concepts
BiologyHost (biology)Toxoplasma gondiiVirologyGeneticsCell biologyAntibodyToxoplasma gondii Research StudiesAutophagy in Disease and TherapyHeme Oxygenase-1 and Carbon Monoxide