Polyphenols Mediate Neuroprotection in Cerebral Ischemic Stroke—An Update
Salaheldin Abdelraouf Abdelsalam, Kaviyarasi Renu, Hamad Abu Zahra, Basem M. Abdallah, Enas M. Ali, Vishnu Priya Veeraraghavan, Kalaiselvi Sivalingam, Larance Ronsard, Rebaï Ben Ammar, Devanathadesikan Seshadri Vidya, Palaniyandi Karuppaiya, Saeed Y. Al‐Ramadan, Peramaiyan Rajendran
Abstract
Stroke is one of the main causes of mortality and disability, and it is due to be included in monetary implications on wellbeing frameworks around the world. Ischemic stroke is caused by interference in cerebral blood flow, leading to a deficit in the supply of oxygen to the affected region. It accounts for nearly 80-85% of all cases of stroke. Oxidative stress has a significant impact on the pathophysiologic cascade in brain damage leading to stroke. In the acute phase, oxidative stress mediates severe toxicity, and it initiates and contributes to late-stage apoptosis and inflammation. Oxidative stress conditions occur when the antioxidant defense in the body is unable to counteract the production and aggregation of reactive oxygen species (ROS). The previous literature has shown that phytochemicals and other natural products not only scavenge oxygen free radicals but also improve the expressions of cellular antioxidant enzymes and molecules. Consequently, these products protect against ROS-mediated cellular injury. This review aims to give an overview of the most relevant data reported in the literature on polyphenolic compounds, namely, gallic acid, resveratrol, quercetin, kaempferol, mangiferin, epigallocatechin, and pinocembrin, in terms of their antioxidant effects and potential protective activity against ischemic stroke.