Silicon-enriched functional meat enhances colonic barrier function by regulating tight junction protein expression, oxidative stress, and inflammation responses in a diabetic dyslipidemia model
Marina Hernández‐Martín, Aránzazu Bocanegra, Alba Garcimartín, Adrián Macho‐González, Rocío Redondo‐Castillejo, Rosa A. García‐Fernández, Luis Apaza Ticona, Sara Bastida, Juana Benedı́, Francisco J. Sánchez‐Muniz, María Elvira López‐Oliva
Abstract
the pNrf2 pathway and superoxide dismutase activity. Furthermore, silicon reduced the pro-inflammatory cytokines TNFα and IL-6, likely through inhibition of the TLR4/NFκB pathway. The results suggest that silicon's ability to enhance intestinal barrier integrity, reduce oxidative stress, and prevent inflammation could slow down T2DM progression, making it a promising nutritional adjuvant for managing the disease.
Topics & Concepts
DyslipidemiaInsulin resistanceOxidative stressInflammationEndocrinologyInternal medicineDiabetes mellitusType 2 Diabetes MellitusMedicineBarrier functionBiologyCell biologySelenium in Biological SystemsFood composition and propertiesNutritional Studies and Diet