Tumor-derived exosomal microRNA-7-5p enhanced by verbascoside inhibits biological behaviors of glioblastoma in vitro and in vivo
Huan Wang, Jiugeng Feng, Ao Fan, Yiqiang Tang, Pengliang Xu, Min Wang, Min Huang
Abstract
. Overall, VB can promote the expression of miR-7-5p in GBM cells and transfer miR-7-5p via exosomes, thereby inhibiting the occurrence of GBM.
Topics & Concepts
MicrovesiclesCancer researchProtein kinase BIn vivoPI3K/AKT/mTOR pathwaymicroRNAMetastasisVerbascosideEpidermal growth factor receptorIn vitroApoptosisChemistryBiologySignal transductionMedicineCell biologyReceptorCancerInternal medicineBiochemistryGlycosideOrganic chemistryGeneBiotechnologyExtracellular vesicles in diseaseNatural product bioactivities and synthesisEssential Oils and Antimicrobial Activity