RidA Proteins Protect against Metabolic Damage by Reactive Intermediates
Jessica Irons, Kelsey Hodge‐Hanson, Diana M. Downs
Abstract
The Rid (YjgF/YER057c/UK114) protein superfamily was first defined by sequence homology with available protein sequences from bacteria, archaea, and eukaryotes (L. Parsons, N. Bonander, E. Eisenstein, M. Gilson, et al., Biochemistry 42:80–89, 2003, https://doi.org/10.1021/bi020541w ). The archetypal subfamily, RidA (reactive intermediate deaminase A), is found in all domains of life, with the vast majority of free-living organisms carrying at least one RidA homolog.
Topics & Concepts
BiologySubfamilyArchaeaHomology (biology)BacteriaSequence homologySUPERFAMILYGeneticsBiochemistryComputational biologyEvolutionary biologyPeptide sequenceAmino acidGeneEnzyme Structure and FunctionGenomics and Phylogenetic StudiesBiochemical and Molecular Research