Unprecedented sesterterpenoids, orientanoids A–C: discovery, bioinspired total synthesis and antitumor immunity
Cheng‐Yu Zheng, Jin‐Xin Zhao, Chang-Hao Yuan, Xia Peng, Meiyu Geng, Jing Ai, Yao‐Yue Fan, Jian‐Min Yue
Abstract
We report a holistic study of the isolation, structure elucidation, total syntheses, and biological evaluation of three unprecedented sesterterpenoids, orientanoids A–C (1–3).
Topics & Concepts
Isolation (microbiology)Computational biologyTotal synthesisDrug discoveryChemistryBiologyStereochemistryBioinformaticsBiochemistryMarine Sponges and Natural ProductsSynthetic Organic Chemistry MethodsBiological Activity of Diterpenoids and Biflavonoids