N<sup>6</sup>‑methyladenosine‑induced long non‑coding RNA PVT1 regulates the miR‑27b‑3p/BLM axis to promote prostate cancer progression
Bin Chen, Chang Liu, Hong Long, Guohui Bai, Yuhang Zhu, Houqiang Xu
Abstract
. The overexpression of PVT1 contributed to the aggressive phenotype of PCa cells by regulating the miR‑27b‑3p/BLM axis. On the whole, the findings of the present study may provide novel potential targets for the treatment of PCa.
Topics & Concepts
PVT1BiologyGene knockdownCancer researchOncogeneMALAT1Molecular biologymicroRNADownregulation and upregulationLong non-coding RNACellCell cycleCell cultureGeneGeneticsRNA modifications and cancerCancer-related molecular mechanisms researchRNA Research and Splicing