TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination
Guixin Zhu, Meenhard Herlyn, Xiaolu Yang
Topics & Concepts
MAPK/ERK pathwayUbiquitinUbiquitin ligaseCell biologyKinasePhosphorylationDeubiquitinating enzymeDownregulation and upregulationLysineSignal transductionExtracellularChemistryCancer researchBiologyBiochemistryAmino acidGeneMelanoma and MAPK PathwaysUbiquitin and proteasome pathwaysinterferon and immune responses