NuMA forms condensates through phase separation to drive spindle pole assembly
Huixian Ma, Feifei Qi, Ji Li, Songbo Xie, Jie Ran, Min Liu, Jinmin Gao, Jun Zhou
Abstract
Chromosome movement in mitosis is orchestrated by a microtubule-based protein machinery called the mitotic spindle The bipolar organization of the mitotic spindle is essential for the accurate segregation of chromosomes into daughter cells. Defects in bipolar spindle assembly can cause chromosome instability and aneuploidy, which are frequently observed in malignant tumors The nuclear mitotic apparatus (NuMA) is a protein critical for bipolar spindle organization primarily due to its functions in the formation of spindle poles. Dysregulation of NuMA has been reported in a number of cancer types and is associated with cancer development Therefore, it is of great significance to understand the molecular mechanisms by which NuMA contributes to spindle pole assembly.