Emerging Transcriptional and Genomic Mechanisms Mediating Carbapenem and Polymyxin Resistance in <i>Enterobacteriaceae</i> : a Systematic Review of Current Reports
Masego Mmatli, Nontombi Mbelle, Nontuthuko Excellent Maningi, John Osei Sekyere
Abstract
The spread of carbapenem- and polymyxin-resistant Enterobacteriaceae poses a significant threat to public health, challenging clinicians worldwide with limited therapeutic options. This review describes the current coding and noncoding genetic and transcriptional mechanisms mediating carbapenem and polymyxin resistance, respectively.
Topics & Concepts
PolymyxinCarbapenem-resistant enterobacteriaceaeEnterobacteriaceaeCarbapenemBiologyMicrobiologyMedicineComputational biologyGeneticsGeneAntibioticsEscherichia coliAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyPharmaceutical and Antibiotic Environmental Impacts