γ-Secretase inhibitors and modulators: Mechanistic insights into the function and regulation of γ-Secretase
Pengju Nie, Abhishek Vartak, Yue‐Ming Li
Topics & Concepts
BiologyAllosteric regulationFunction (biology)Amyloid precursor protein secretasePresenilinComputational biologyProteaseNeuroscienceGamma secretaseEnzymeCell biologyBiochemistryDiseaseAlzheimer's diseaseAmyloid precursor proteinMedicinePathologyATP Synthase and ATPases ResearchProtein Structure and DynamicsComputational Drug Discovery Methods