Genomic Variation across a Clinical Cryptococcus Population Linked to Disease Outcome
Poppy Sephton-Clark, Jennifer L. Tenor, Dena L. Toffaletti, Nancy Meyers, Charles Giamberardino, Síle F. Molloy, Julia R. Palmucci, Adrienne K Chan, Tarsizio Chikaonda, Robert S. Heyderman, Mina C. Hosseinipour, Newton Kalata, Cecilia Kanyama, Christopher Kukacha, Duncan Lupiya, Henry C. Mwandumba, Thomas S. Harrison, Tihana Bicanic, John R. Perfect, Christina A. Cuomo
Abstract
growth data, we utilize genome-wide association approaches to examine the genetic basis of virulence. Genes with significant associations display virulence attributes in both murine and rabbit models, demonstrating that our approach can identify potential links between genetic variants and patho-biologically significant phenotypes.
Topics & Concepts
Cryptococcus neoformansCryptococcosisBiologyImmune systemCryptococcusDiseasePathogenPopulationHost (biology)Fungal pathogenGenetic variationGeneticsImmunologyMedicineGeneEnvironmental healthPathologyFungal Infections and StudiesNail Diseases and TreatmentsAntifungal resistance and susceptibility