Reductive Hydroformylation of Isosorbide Diallyl Ether
Jérémy Ternel, Adrien Lopes, Mathieu Sauthier, C. Buffe, Vincent Wiatz, Hervé Bricout, Sébastien Tilloy, Éric Monflier
Abstract
Isosorbide and its functionalized derivatives have numerous applications as bio-sourced building blocks. In this context, the synthesis of diols from isosorbide diallyl ether by hydrohydroxymethylation reaction is of extreme interest. This hydrohydroxymethylation, which consists of carbon-carbon double bonds converting into primary alcohol functions, can be obtained by a hydroformylation reaction followed by a hydrogenation reaction. In this study, reductive hydroformylation was achieved using isosorbide diallyl ether as a substrate in a rhodium/amine catalytic system. The highest yield in bis-primary alcohols obtained was equal to 79%.