A Double-Edged Sword: The Anti-Cancer Effects of Emodin by Inhibiting the Redox-Protective Protein MTH1 and Augmenting ROS in NSCLC
Divya Wahi, Deepika Soni, Abhinav Grover
Abstract
Based on our data, the anti-cancer effects of emodin as an MTH1 inhibitor have clinical potential as a single agent capable of functioning as a ROS inducer and simultaneous blocker of dNTP pool sanitation in the treatment of NSCL cancers. Collectively, our results have identified for the first time that the potential molecular mechanism of emodin function, increasing DNA damage and apoptosis in cancer cells, is via MTH1 inhibition.
Topics & Concepts
SWORDEmodinRedoxPharmacologyCancer researchChemistryMedicineBiochemistryComputer scienceWorld Wide WebOrganic chemistryBioactive Compounds and Antitumor AgentsPhytochemistry and biological activity of medicinal plantsGenomics, phytochemicals, and oxidative stress