Palladium-catalyzed selective B(3)–H arylation of <i>o</i>-carboranes with arylboronic acids at room temperature
Ziyi Yang, Yuanbo Wu, Yatong Fu, Jianxin Yang, Jian Lu, Jian Lu, Ju-You Lu, Ju-You Lu
Abstract
A palladium-catalyzed selective B(3)-H arylation of o-carboranes at room temperature has been developed using readily available arylboronic acids as the aryl source, and the corresponding 3-aryl-o-carboranes were obtained in good to excellent yields. This method provides a powerful synthetic route for constructing polysubstituted o-carborane derivatives.
Topics & Concepts
PalladiumArylCatalysisChemistryMedicinal chemistryCombinatorial chemistryOrganic chemistryAlkylBoron Compounds in ChemistryOrthopedic Infections and TreatmentsRadiopharmaceutical Chemistry and Applications