COVID-19-related collapsing glomerulopathy revealing a rare risk variant of APOL1: lessons for the clinical nephrologist
Timothée Laboux, Jean‐Baptiste Gibier, Nicolas Pottier, François Glowacki, Aghilès Hamroun
Abstract
The case A 57-year-old patient of Congolese origin with a medical history of hypertension under triple therapy was referred to the emergency department due to significant deterioration in general condition, loss of 10 kg in one month, fever, anosmia and ageusia. He also reported a few episodes of non-bloody diarrhea and oliguria. Laboratory findings revealed severe acute kidney failure (serum creatinine at 30.3 mg/dL versus 0.8 mg/dL one month earlier, blood urea nitrogen at 536 mg/ dL), hyperkaliemia at 7.4 mmol/L, and low bicarbonatemia at 13 mmol/L (Supplemental table). There was glomerularrange proteinuria with urinary protein-to-creatinine ratio (uPCR) at 1.2 g/g including 0.6 g/g of albuminuria and