Deletion of fatty acid transport protein 2 (FATP2) in the mouse liver changes the metabolic landscape by increasing the expression of PPARα-regulated genes
Vincent M. Perez, Jeffrey Gabell, Mark Behrens, Nishikant Wase, Concetta Dirusso, Paul N. Black
Abstract
liver revealed increases of total C16:0, C16:1, and C18:1 fatty acids; increases in lipoxin A4 and prostaglandin J2; and a decrease in 20-hydroxyeicosatetraenoic acid. We conclude that the expression of FATP2 in the liver broadly affects the metabolic landscape through PPARα, indicating that FATP2 provides an important role in liver lipid metabolism through its transport or activation activities.
Topics & Concepts
Peroxisome proliferator-activated receptorBiologyTranscriptomePeroxisomeFatty acidFatty acid metabolismArachidonic acidBeta oxidationFatty liverLipid metabolismadipocyte protein 2Gene expressionEndocrinologyInternal medicineBiochemistryGeneMedicineDiseaseEnzymePeroxisome Proliferator-Activated ReceptorsDrug Transport and Resistance MechanismsMetabolism and Genetic Disorders