Overexpression of laminin-5 gamma-2 promotes tumorigenesis of pancreatic ductal adenocarcinoma through EGFR/ERK1/2/AKT/mTOR cascade
Anuradha Kirtonia, Amit Kumar Pandey, Balaji Ramachandran, Durga Prasad Mishra, David W. Dawson, Gautam Sethi, Trivadi S. Ganesan, H. Phillip Koeffler, Manoj Garg
Topics & Concepts
Cancer researchCarcinogenesisPI3K/AKT/mTOR pathwayBiologyGene silencingEpithelial–mesenchymal transitionProtein kinase BGene knockdownEpidermal growth factor receptorDownregulation and upregulationMetastasisCancerSignal transductionCell cultureCell biologyBiochemistryGeneticsGeneCell Adhesion Molecules ResearchCancer Cells and MetastasisCaveolin-1 and cellular processes