The nonselective cation channel TRPV4 inhibits angiotensin II receptors
Nicholas W. Zaccor, Charlotte J. Sumner, Solomon H. Snyder
Abstract
/calmodulin-dependent manner, preventing β-arrestin recruitment and receptor internalization. These findings suggest that when TRP channels and GPCRs are co-expressed in the same tissues, many of these channels can inhibit GPCR desensitization.
Topics & Concepts
G protein-coupled receptorInternalizationTransient receptor potential channelTRPV4Cell biologyGq alpha subunitChemistryReceptorArrestinAngiotensin IIG proteinCalcium signalingBiologyBiochemistryIon Channels and ReceptorsReceptor Mechanisms and SignalingNeuropeptides and Animal Physiology