A bispecific nanobody targeting the dimerization interface of epidermal growth factor receptor: Evidence for tumor suppressive actions in vitro and in vivo
Zhimin Xu, Chuangnan Qiu, Biyan Wen, Shuang Wang, Linfeng Zhu, Lin Zhao, Huangjin Li
Topics & Concepts
Antibody-dependent cell-mediated cytotoxicityEpidermal growth factor receptorIn vivoChemistryCancer researchEpidermal growth factorAntibodyMolecular biologyIn vitroA431 cellsPeripheral blood mononuclear cellGrowth factor receptorCytotoxicityBiologyCellReceptorImmunologyBiochemistryCell cycleBiotechnologyMolecular medicineMonoclonal and Polyclonal Antibodies ResearchGlycosylation and Glycoproteins ResearchHER2/EGFR in Cancer Research