Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy
Nicole M. Sayles, Nneka Southwell, Kevin McAvoy, Kihwan Kim, Alba Pesini, Corey J. Anderson, Catarina M. Quinzii, Suzanne M. Cloonan, Hibiki Kawamata, Giovanni Manfredi
Abstract
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Topics & Concepts
ProteostasisMitochondrionBiologyMitochondrial biogenesisBioenergeticsMitochondrial DNACell biologyOxidative stressMitophagyCardiomyopathyBiogenesisGeneticsAutophagyBiochemistryGeneInternal medicineMedicineApoptosisHeart failureGDF15 and Related BiomarkersMitochondrial Function and PathologyRNA modifications and cancer