Comparable Efficacy of Reduced Dose Radiation Therapy for the Treatment of Early Stage Gastric Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue
Omran Saifi, Scott C. Lester, William G. Rule, Bradley J. Stish, Scott Stafford, Deanna Pafundi, Liuyan Jiang, David M. Menke, Muhamad Alhaj Moustafa, Allison Rosenthal, Taimur Sher, Ayala Ernesto, Han W. Tun, Bradford S. Hoppe, Jennifer Peterson
Abstract
PURPOSE: This study compares reduced (<27 Gy) to standard dose (≥30 Gy) radiation therapy (RT) in the treatment of gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (gMALT lymphoma). METHODS AND MATERIALS: Forty-two patients with stage I or II disease were retrospectively reviewed. Response to RT was assessed with endoscopy after RT. Complete response rate (CR), freedom from treatment failure, and overall survival (OS) were calculated. RESULTS: = .001, respectively). However, incidence and severity of reported toxicities were similar between the 2 groups. CONCLUSIONS: Reduced dose RT (23.5-27 Gy) achieved excellent complete response rates with minimal toxicity, comparable with standard dose RT (30-36 Gy), for gMALT.