Prevention of SARS-CoV-2 cell entry: insight from<i>in silico</i>interaction of drug-like alkaloids with spike glycoprotein, human ACE2, and TMPRSS2
Gideon Ampoma Gyebi, Adegbenro P. Adegunloye, Ibrahim M. Ibrahim, Oludare M. Ogunyemi, Saheed O. Afolabi, Olalekan Bukunmi Ogunro
Abstract
evaluation of these "drug-like" alkaloids as potential inhibitors of coronavirus cell entry is proposed.Communicated by Ramaswamy H. Sarma.
Topics & Concepts
In silicoTMPRSS2GlycoproteinBiologyViral entryDocking (animal)Plasma protein bindingBiochemistryBinding siteTransmembrane domainDrug discoveryChemistryAmino acidVirusVirologyViral replicationGenePathologyMedicineNursingDiseaseInfectious disease (medical specialty)Coronavirus disease 2019 (COVID-19)Cancer therapeutics and mechanismsToxin Mechanisms and ImmunotoxinsComputational Drug Discovery Methods