Induction of ER stress-mediated apoptosis through SOD1 upregulation by deficiency of CHI3L1 inhibits lung metastasis
Ji Eun Yu, In Jun Yeo, Seung Sik Yoo, Sung‐Hyun Kim, Dong Ju Son, Jaesuk Yun, Sang‐Bae Han, Jin Tae Hong
Abstract
models. These results suggest that the depletion of CHI3L1 increases ER stress-mediated apoptotic cell death through SOD1 expression, and subsequently inhibits lung metastasis.
Topics & Concepts
Unfolded protein responseEndoplasmic reticulumCell biologyXBP1TransfectionDownregulation and upregulationCancer cellProtein kinase RChemistryKinaseBiologyProtein kinase ACancer researchCancerCell cultureMitogen-activated protein kinase kinaseBiochemistryRNARNA splicingGeneticsGeneEndoplasmic Reticulum Stress and DiseaseStudies on Chitinases and ChitosanasesAutophagy in Disease and Therapy