Peroxidase-like MoS2/Ag nanosheets with synergistically enhanced NIR-responsive antibacterial activities
Huiying Chen, Xinshuo Zhao, Bingbing Cui, Haohao Cui, Mengyang Zhao, Jun Shi, Jingguo Li, Zhan Zhou
Abstract
Pathogenic microbial infections have been threatening public health all over the world, which makes it highly desirable to develop an antibiotics-free material for bacterial infection. In this paper, molybdenum disulfide (MoS 2 ) nanosheets loaded with silver nanoparticles (Ag NPs) were constructed to inactive bacteria rapidly and efficiently in a short period under a near infrared (NIR) laser (660 nm) in the presence of H 2 O 2 . The designed material presented favorable features of peroxidase-like ability and photodynamic property, which endowed it with fascinating antimicrobial capacity. Compared with free MoS 2 nanosheets, the MoS 2 /Ag nanosheets (denoted as MoS 2 /Ag NSs) exhibited better antibacterial performance against Staphylococcus aureus by the generated reactive oxygen species (ROS) from both peroxidase-like catalysis and photodynamic, and the antibacterial efficiency of MoS 2 /Ag NSs could be further improved by increasing the amount of Ag. Results from cell culture tests proved that MoS 2 /Ag3 nanosheets had a negligible impact on cell growth. This work provided new insight into a promising method for eliminating bacteria without using antibiotics, and could serve as a candidate strategy for efficient disinfection to treat other bacterial infections.