Construction of biodegradable core cross-linked nanoparticles from near infrared dyes encoded in polyprodrug amphiphiles and investigation of their synergistic anticancer activity
Xiaoxu Mao, Shoukui Hu, Ke Shang, Guangwei Yang, Jinhao Yan, Chao Ma, Jun Yin
Abstract
Amphiphilic polyprodrugs with reduction-responsive camptothecin prodrug and photothermal converted IR780 dyes was performed<italic>via</italic>core cross-linking protocol. The nanoparticles could be served as a nanocarrier and presented severe cytotoxicity to HeLa cells.
Topics & Concepts
AmphiphileNanocarriersCamptothecinHeLaChemistryProdrugNanoparticleCytotoxicityPhotothermal therapyCombinatorial chemistryCore (optical fiber)BiophysicsNanotechnologyOrganic chemistryCellBiochemistryMaterials sciencePolymerCopolymerIn vitroBiologyComposite materialNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery