Histidine decarboxylase-expressing PMN-MDSC-derived TGF-β1 promotes the epithelial-mesenchymal transition of metastatic lung adenocarcinoma.
Xiao-Gang Fu, Jun Deng, Wen-Jun Xu, Jinyan Chen, Jian Sun, Huan Deng
Abstract
PMN-MDSCs, which, in turn, express TGF-β1 to induce cancer cells to undergo EMT at metastatic sites.
Topics & Concepts
MetastasisEpithelial–mesenchymal transitionCancer researchAdenocarcinomaMedicineCXCL1Downregulation and upregulationChemokinePathologyCancerBiologyImmunologyInternal medicineImmune systemGeneBiochemistryCancer Cells and MetastasisEpigenetics and DNA MethylationTGF-β signaling in diseases