Estrogen regulation of germline stem cell differentiation as a mechanism contributing to female reproductive aging
Chonthicha Satirapod, Ning Wang, J. Macdonald, Minghan Sun, Dori C. Woods, Jonathan L. Tilly
Abstract
expression and oocyte numbers; however, both endpoints rebound to control levels after ceasing drug treatment. These findings establish a key physiological role for E2-ERα signaling in promoting OSC differentiation as a potential mechanism to maintain adequate numbers of ovarian follicles during reproductive life.
Topics & Concepts
OogenesisBiologyGermlineEstrogen receptorEndocrinologyInternal medicineOvaryEstrogenOocytePremature ovarian failureAromataseEstrogen receptor alphaCell biologyGeneticsGeneMedicineEmbryoCancerBreast cancerReproductive Biology and FertilityEstrogen and related hormone effectsReproductive System and Pregnancy