5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors
Guozhang Xu, Fuyong Du, Gee‐Hong Kuo, June Xu, Yin Liang, Keith T. Demarest, Michael D. Gaul
Topics & Concepts
ChemistryPostprandialHydroxymethylIn vivoBioavailabilityOral administrationArylPharmacologyD-GlucoseIC50In vitroStereochemistryBiochemistryDiabetes mellitusEndocrinologyOrganic chemistryBiotechnologyMedicineBiologyAlkylDiabetes Treatment and ManagementMetabolism, Diabetes, and CancerDrug Transport and Resistance Mechanisms