Litcius/Paper detail

5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors

Guozhang Xu, Fuyong Du, Gee‐Hong Kuo, June Xu, Yin Liang, Keith T. Demarest, Michael D. Gaul

2020Bioorganic & Medicinal Chemistry Letters13 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryPostprandialHydroxymethylIn vivoBioavailabilityOral administrationArylPharmacologyD-GlucoseIC50In vitroStereochemistryBiochemistryDiabetes mellitusEndocrinologyOrganic chemistryBiotechnologyMedicineBiologyAlkylDiabetes Treatment and ManagementMetabolism, Diabetes, and CancerDrug Transport and Resistance Mechanisms