Ovarian carcinoma immunoreactive antigen–like protein 2 (OCIAD2) is a novel complex III–specific assembly factor in mitochondria
Katarzyna Justyna Chojnacka, Praveenraj Elancheliyan, Ben Hur Marins Mussulini, Karthik Mohanraj, Sylvie Callegari, Aleksandra Gosk, Tomasz Banach, Tomasz Góral, Karolina Szczepanowska, Peter Rehling, Remigiusz Adam Serwa, Agnieszka Chacinska
Abstract
Using a combination of techniques (mass spectrometry, BN–PAGE, immunodetection, and mitochondrial in vitro import assays), it is reported that a previously poorly described protein, OCIAD2, localizes to the inner mitochondrial membrane and participates in the formation of electron transport chain complexes.
Topics & Concepts
BiologyMitochondrionCell biologyBiogenesisHEK 293 cellsTransport proteinBiochemistryMitochondrial biogenesisOvarian carcinomaProtein targetingEnzymeProto-Oncogene Proteins c-mycGeneMicrotubuleMembrane proteinInner mitochondrial membraneOvarian cancerSecretionNuclear proteinMechanism of actionProtein biosynthesisMutationProteomicsMicrotubule-associated proteinPlasma protein bindingMitochondrial Function and PathologyATP Synthase and ATPases ResearchPhotosynthetic Processes and Mechanisms