A c-di-GMP Signaling Cascade Controls Motility, Biofilm Formation, and Virulence in Burkholderia thailandensis
Zhuo Wang, Xiaorong Xie, Daohan Shang, Laigong Xie, Yueyue Hua, Song Li, Yantao Yang, Yao Wang, Xihui Shen, Lei Zhang
Abstract
The transition from planktonic cells to biofilm cells is a successful strategy adopted by bacteria to survive in diverse environments, while the second messenger c-di-GMP plays an important role in this process. Cellular c-di-GMP levels are mainly controlled by modulating the activity of c-di-GMP-metabolizing proteins via the sensory domains adjacent to their enzymatic domains.
Topics & Concepts
BiofilmBiologyVirulenceOperonCell biologyMotilitySecond messenger systemMicrobiologyBiochemistryIntracellularBurkholderiaPAS domainBacteriaEscherichia coliGeneGeneticsTranscription factorBacterial biofilms and quorum sensingAntibiotic Resistance in BacteriaLegume Nitrogen Fixing Symbiosis