Defluorinative [4 + 1] annulation of perfluoroalkyl <i>N</i>-mesylhydrazones with primary amines provides 5-fluoroalkyl 1,2,3-triazoles
Yongquan Ning, Hongwei Wang, Paramasivam Sivaguru, Shuang Li, Giuseppe Zanoni, Steven P. Nolan, Xihe Bi
Abstract
A novel azide-free approach for the synthesis of 5-perfluoroalkyl-1,2,3-triazoles via the [4 + 1] annulation of perfluoroalkyl N -mesylhydrazones (PFHZ-Ms) with primary amines was realized under mild conditions.
Topics & Concepts
AnnulationPrimary (astronomy)ChemistryAzideTriazoleCombinatorial chemistryOrganic chemistryMedicinal chemistryCatalysisPhysicsAstronomyFluorine in Organic ChemistryClick Chemistry and ApplicationsCyclopropane Reaction Mechanisms