Cancer-associated fibroblasts reprogram cysteine metabolism to increase tumor resistance to ferroptosis in pancreatic cancer
Yuchao Zhu, Shuai Fang, Bolin Fan, Kaiwei Xu, Xu Liu, Linwei Wang, Lubin Zhu, Chunqu Chen, Ruoyu Wu, Jiajing Ni, Jianhua Wang
Abstract
Taken together, the findings demonstrate a novel metabolic relationship between CAFs and cancer cells, in which cysteine generated by CAFs acts as a substrate in the prevention of oxidative damage in PDAC and thus suggests new therapeutic targets for PDAC.
Topics & Concepts
Pancreatic cancerTumor microenvironmentCancer researchCysteine metabolismGlutathioneCancer cellCancerCancer-Associated FibroblastsCysteineChemistryBiologyMedicineBiochemistryInternal medicineTumor cellsEnzymeEpigenetics and DNA MethylationFerroptosis and cancer prognosisCancer, Hypoxia, and Metabolism