The global Protein-RNA interaction map of ESRP1 defines a post-transcriptional program that is essential for epithelial cell function
Natoya Peart, Jae Yeon Hwang, Mathieu Quesnel-Vallières, Matthew J. Sears, Yuequin Yang, Peter Stoilov, Yoseph Barash, Juw Won Park, Kristen W. Lynch, Russ P. Carstens
Abstract
. These studies demonstrated that ESRP1 functions in splicing regulation occur primarily through direct binding in a position-dependent manner to promote either exon inclusion or skipping. In addition, we also identified widespread binding of ESRP1 in 3' and 5' untranslated regions (UTRs) of genes involved in epithelial cell function, suggesting that its post-transcriptional functions extend beyond splicing regulation.
Topics & Concepts
Alternative splicingRNA splicingRNA-binding proteinBiologyExonCell biologyGeneImmunoprecipitationSplicing factorUntranslated regionGeneticsRNARNA Research and SplicingGenomics and Chromatin DynamicsRNA modifications and cancer