A Copper‐Catalyzed Sonogashira Coupling Reaction of Diverse Activated Alkyl Halides with Terminal Alkynes Under Ambient Conditions
Yuxi Cao, Xiaoyang Dong, Jun Yang, Shengpeng Jiang, Shuangliu Zhou, Zhong‐Liang Li, Guo‐Qiang Chen, Xin‐Yuan Liu
Abstract
Abstract We describe a copper‐catalyzed Sonogashira coupling reaction of alkyl halides with terminal alkynes under ambient conditions, efficiently providing a versatile tool for the construction of substituted alkynes. A new proline‐based N,N,P‐ligand is utilized to promote the transformation under a mild reaction condition. Diverse alkyl halides, such as primary and secondary (hetero)benzyl chlorides and bromides, secondary and tertiary α‐bromo amides and propargylic bromide, are applicable to provide a wide array of alkynes. magnified image
Topics & Concepts
ChemistrySonogashira couplingHalideAlkylCatalysisCopperAlkyneLigand (biochemistry)Coupling reactionBromideCombinatorial chemistryOrganic chemistryMedicinal chemistryPalladiumBiochemistryReceptorCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsRadical Photochemical Reactions