A dietary ketone ester mitigates histological outcomes of NAFLD and markers of fibrosis in high-fat diet fed mice
Mary P. Moore, Rory P. Cunningham, Rachel Davis, Sarah E. Deemer, Brandon M. Roberts, Eric P. Plaisance, R. Scott Rector
2021American Journal of Physiology-Gastrointestinal and Liver Physiology25 citationsDOIOpen Access PDF
Abstract
To our knowledge, this is the first study focusing on hepatic outcomes in response to dietary ketone ester feeding in male mice with HFD-induced NAFLD. Novel findings include that dietary ketone ester feeding ameliorates NAFLD outcomes via reductions in histological steatosis and inflammation. These improvements were beyond those observed for caloric restriction alone. Furthermore, dietary ketone ester feeding was associated with greater reductions in markers of hepatic fibrogenesis and inflammation compared with control and calorie-restricted mice.
Topics & Concepts
SteatosisKetone bodiesInflammationKetoneInternal medicineFibrosisCalorieEndocrinologyMedicineGastroenterologyChemistryMetabolismOrganic chemistryLiver Disease Diagnosis and TreatmentDiet and metabolism studiesDiet, Metabolism, and Disease