CRISPR-Cas9 based gene editing of the immune checkpoint NKG2A enhances NK cell mediated cytotoxicity against multiple myeloma
Tobias Bexte, Jamal Alzubi, Lisa Marie Reindl, Philipp Wendel, Ralf Schubert, Emilia Salzmann‐Manrique, Ivana von Metzler, Toni Cathomen, Evelyn Ullrich
Abstract
-editing in primary NK cells has the prospect of overcoming immune checkpoint inhibition in clinical applications.
Topics & Concepts
Immune systemCytotoxic T cellCancer researchBiologyCytotoxicityImmunotherapyImmune checkpointImmunologyIn vitroBiochemistryImmune Cell Function and InteractionCAR-T cell therapy researchT-cell and B-cell Immunology