The involvement of the <i>Candida glabrata</i> trehalase enzymes in stress resistance and gut colonization
Mieke Van Ende, Bea Timmermans, Giel Vanreppelen, Sofía Siscar-Lewin, Daniel Fischer, Stefanie Wijnants, Celia Lobo Romero, Saleh Yazdani, Ona Rogiers, Liesbeth Demuyser, Griet Van Zeebroeck, Yuke Cen, Karl Kuchler, Sascha Brunke, Patrick Van Dijck
Abstract
deletion strain in human macrophages. No significant phenotype was observed for Nth2. The triple deletion strain was unable to establish a stable colonization of the gastrointestinal (GI) tract in mice indicating the importance of having trehalase activity for colonization in the gut.
Topics & Concepts
BiologyTrehalaseMicrobiologyCandida glabrataColonisation resistanceColonizationTrehalosePathogenVirulenceEnzymeCandida albicansGeneBiochemistryAntifungal resistance and susceptibilityFungal Infections and StudiesProbiotics and Fermented Foods