New insight in understanding the contribution of SGLT1 in cardiac glucose uptake: evidence for a truncated form in mice and humans
Laura Ferté, Alice Marino, Sylvain Battault, Laurent Bultot, Anne Van Steenbergen, Anne Bol, Julien Cumps, Audrey Ginion, Hermann Koepsell, Laure Dumoutier, Louis Hue, Sandrine Horman, Luc Bertrand, Christophe Beauloye
Abstract
Ever since the discovery of its expression in the heart, SGLT1 has been considered as similar as the intestine and a potential contributor to cardiac glucose transport. For the first time, we have demonstrated that a slc5a1 transcript variant is present in the heart that has no significant impact on cardiac glucose handling.
Topics & Concepts
PhlorizinGlucose transporterGlucose uptakeGLUT4Internal medicineCotransporterEndocrinologyBasal (medicine)TransporterCarbohydrate metabolismGLUT1BiologyInsulinChemistryBiochemistrySodiumMedicineGeneOrganic chemistryDiabetes Treatment and ManagementMetabolism, Diabetes, and CancerPancreatic function and diabetes