Inhibition of NLRP3 inflammasome activation and pyroptosis with the ethyl acetate fraction of<i>Bungeanum</i>ameliorated cognitive dysfunction in aged mice
Meihuan Zhao, Dai Yuan, Ping Li, Jie Wang, Tengyun Ma, Shijun Xu
Abstract
A schematic illustration of the research. The ethyl acetate active fraction of Bungeanum ameliorated cognitive deficits in aged mice, and its effects may be related to ameliorating oxidative stress and suppressing the NLRP3 inflammasome pathway and GSDMD-mediated pyroptosis.
Topics & Concepts
PyroptosisInflammasomeChemistryOxidative stressEthyl acetatePharmacologyCognitive declineBiochemistryInternal medicineMedicineReceptorDementiaDiseaseInflammasome and immune disordersTryptophan and brain disordersGenomics, phytochemicals, and oxidative stress