Neoadjuvant chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: Meta-analysis and trial sequential analysis of randomized controlled trials
Shahab Hajibandeh, Shahin Hajibandeh, Christina Intrator, Karim Hassan, Mantej Sehmbhi, Jigar Shah, Eshan Mazumdar, Ambareen Kausar, Thomas Satyadas
Abstract
= 0.57) of patients with RPC. Neoadjuvant CRT might be beneficial for patients with BRPC, but not for patients with RPC. Nevertheless, the best available evidence does not include contemporary chemotherapy regimens. Patients with RPC and those with BRPC should not be combined in the same cohort in future studies.
Topics & Concepts
MedicineMeta-analysisRandomized controlled trialPancreatic cancerNeoadjuvant therapyChemoradiotherapyOncologyInternal medicineSurgeryChemotherapyCancerBreast cancerPancreatic and Hepatic Oncology ResearchPancreatitis Pathology and TreatmentNeuroendocrine Tumor Research Advances