Active targeted delivery of theranostic thermo/pH dual-responsive magnetic Janus nanoparticles functionalized with folic acid/fluorescein ligands for enhanced DOX combination therapy of rat glioblastoma
Bahareh Haji Ali, Sepideh Khoee, Fariba Mafakheri, Elahe Sadri, Vahid Pirhajati Mahabadi, Mohammad Reza Karimi, Sakine Shirvalilou, Samideh Khoei
Abstract
gene. Remarkably, this combination treatment did not cause any hepatotoxicity. This study highlights the potential of DOX/MJNPs-FLA as carriers for therapeutic and diagnostic agents in the context of theranostic applications for the treatment of brain malignancies. Additionally, it demonstrates the promising performance of DOX/MJNPs-FLA in combination treatment through passive and active targeting.
Topics & Concepts
Folic acidFluoresceinFolate receptorDoxorubicinChitosanNanoparticleChemistryDrug deliveryGlioblastomaMagnetic nanoparticlesLigand (biochemistry)Combination therapyJanusMaterials scienceNanotechnologyPharmacologyCancer researchFluorescenceReceptorMedicineChemotherapySurgeryBiochemistryOrganic chemistryCancerCancer cellInternal medicinePhysicsQuantum mechanicsNanoparticle-Based Drug DeliveryPickering emulsions and particle stabilizationIntracranial Aneurysms: Treatment and Complications