Discovery of small molecule acting as multitarget inhibitor of colorectal cancer by simultaneous blocking of the key COX-2, 5-LOX and PIM-1 kinase enzymes
Mostafa M. M. El-Miligy, Ahmed K. Al-Kubeisi, Saad R. El‐Zemity, Rasha A. Nassra, Marwa M. Abu‐Serie, A. A. B. HAZZAA
Topics & Concepts
ChemistryCelecoxibIn vivoPharmacologyKinaseColorectal cancerDiclofenac SodiumEnzymePharmacophoreCancerCell cultureBiochemistryInternal medicineBiologyMedicineBiotechnologyChromatographyGeneticsCancer Mechanisms and TherapySynthesis and biological activityBioactive Compounds and Antitumor Agents