A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression
Francesco Cilenti, Giulia Barbiera, Nicoletta Caronni, Dario Iodice, Elisa Montaldo, Simona Barresi, Eleonora Lusito, Vincenzo Cuzzola, Francesco Maria Vittoria, Luca Mezzanzanica, Paolo Miotto, Pietro Di Lucia, Dejan Lazarević, Daniela María Cirillo, Matteo Iannacone, Marco Genua, Renato Ostuni
Abstract
interfered with LPS-mediated activation of ERK5, a known transcriptional partner of MEF2. This study highlights principles of plasticity and adaptation in cells exposed to a complex environment and uncovers a transcriptional circuit for IFN I induction with relevance for infectious diseases or cancer.
Topics & Concepts
BiologyEnhancerCell biologyTranscription factorMef2Gene expressionInnate immune systemRegulation of gene expressionImmune systemContext (archaeology)GeneTranscriptional regulationGeneticsPaleontologyinterferon and immune responsesImmune cells in cancerNF-κB Signaling Pathways