INT-777 prevents cognitive impairment by activating Takeda G protein-coupled receptor 5 (TGR5) and attenuating neuroinflammation via cAMP/ PKA/ CREB signaling axis in a rat model of sepsis
Peng Jin, Shuixiang Deng, Mi Tian, Cameron Lenahan, Pengju Wei, Yao Wang, Jiaying Tan, Huimei Wen, Feng Zhao, Yanqin Gao, Ye Gong
Topics & Concepts
G protein-coupled bile acid receptorMorris water navigation taskMedicineHippocampusNeuroinflammationNeuroprotectionSepsisCREBPharmacologyWestern blotInternal medicineReceptorInflammationBiologyBiochemistryGeneTranscription factorIntensive Care Unit Cognitive DisordersSepsis Diagnosis and TreatmentImmune Response and Inflammation