Chemodivergent C(sp3)–H and C(sp2)–H cyanomethylation using engineered carbene transferases
Juner Zhang, Ailiena O. Maggiolo, Edwin Alfonzo, Runze Mao, Nicholas J. Porter, Nayla M. Abney, Frances H. Arnold
Topics & Concepts
CarbeneChemistrySubstrate (aquarium)ChemoselectivityStereochemistryAlkylationMoleculeEnzymeCombinatorial chemistryCatalysisSurface modificationOrganic chemistryBiologyPhysical chemistryEcologyCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions